NEUROPHARMACOLOGICAL STUDIES OF EFFECT OF NEW CENTRAL DEPRESSANT, 8-CHLORO-6-PHENYL-4H-s-TRIAZOLO [4, 3-a] [1, 4] BENZODIAZEPINE (D-40TA) ON EEG AND CENTRAL SYMPATHETIC ACTIVATING MECHANISM IN CATS
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概要
- 論文の詳細を見る
The present study regarding the effects of 8-chloro-6-phenyl-4H-s-triazolo [4, 3-a] [1, 4] benzodiazepine (D-40TA) on the EEG arousal and sympathetic excitatory responses evoked spontaneously or by stimulation of the midbrain reticular formation, posterior hypothalamus, thalamus and sciatic nerve in the curarized, intact brain or cerveau isolé cats provided the following conclusion: D-40TA reduced the central sympathetic excitability by depressing the hypothalamus and its related structures, and limited the persistence of the EEG arousal by selective depression of the hypothalamic and probably midbrain mechanism relevant to a "tonic" EEG component with much less influence upon a "phasic" EEG component related to waking ability itself. These dual effects may be responsible for hypnogcnic action of D-40TA.
- 公益社団法人 日本薬理学会の論文
著者
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NAGAWA Yuji
Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd
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SAJI Yoshiaki
Biological Research Laboratories, Central Research Division, Takerla Chemical Industries, Ltd.
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Fukuda Naohisa
Biological Research Laboratories, Central Research Division, Takerla Chemical Industries, Ltd.
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NAGAWA Yuji
Biological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.
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NAGAWA Yuji
Biological Research Laboratories, Central Research Division, Takerla Chemical Industries, Ltd.
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