BLOCKADE BY ESERINE OF THE CEREBRAL CORTICAL EFFECTS OF ALLOFERIN: A FURTHER EVIDENCE OF CHOLINERGIC INHIBITORY MECHANISM

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概要

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• In rats anaesthetised with pentobarbitonc, somatosensory evoked potentials, produced by stimulation of contralatcral or ipsilateral forepaws were used tc measure the activity in different neuronal pathways. Computer derived averages of 32 consecutive responses yielded a stable and consistent measurement of the evoked potentials. The drugs were applied to the cerebral cortex by using cortical cup technique and changes were measured in evoked potentials. Coriical application of alloferin increased the amplitude of the early negative wave of the cortical evoked potentials. This effect of alloferin was blocked by prior treatment of the cortex with eserine. It appears that the excitant effect of alloferin on the cortex was the result of disinhibition of cortical cholinergic inhibitory mechanism.

• 社団法人 日本薬理学会の論文

著者

• BHARGAVA Vinod

  Department of Pharmacology, H.P. Medical College

関連論文

• CHOLINERGIC MECHANISM IN THE CEREBRAL CORTEX—A FURTHER STUDY WITH ACETYL-β-METHYLCHOLINE (METHACHOLINE)
• BLOCKADE BY ESERINE OF THE CEREBRAL CORTICAL EFFECTS OF ALLOFERIN: A FURTHER EVIDENCE OF CHOLINERGIC INHIBITORY MECHANISM

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