EFFECTS OF 1-MORPHOLINOACETYL-2-METHYL-3-PHENYL-4-OXO-1, 2, 3, 4-TETRAHYDROQUINAZOLINE HYDROCHLORIDE (HQ-275) ON ACUTE EXPERIMENTAL HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE IN RATS

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概要

• 論文の詳細を見る

• Pharmacological effects of HQ-275 on CCl<SUB>4</SUB>-liver injury have been investigated, and the results compared with those of rats treated with CCl<SUB>4</SUB> plus HQ-275 with those of normal rats and only CCl<SUB>4</SUB>-treated rats. In the excretion test of biliary flow, bilirubin, solid contents and B•S•P, rats treated with CCl<SUB>4</SUB>, alone or with CCl<SUB>4</SUB>, plus HQ-275 showed less excretion than those of normal rats, and the differences among these three categories were not significant. HQ-275 revealed a potent recovery process from the liver damage caused by CCl<SUB>4</SUB>, in both histological and biological levels. Changes of Na<SUP>+</SUP> and K<SUP>+</SUP> in bile, water content of liver and body temp. were recognized among the three groups. It can be concluded from over-all results that there may be some differences between structural and functional recovery processes from CCl<SUB>4</SUB>-hepatotoxicity.

• 公益社団法人 日本薬理学会の論文

著者

• KOWA Yoshio

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.

• HORI Masaki

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.

• Ochial Takashi

  Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.

関連論文

• CHOLERETIC ACTIVITIES OF 1-MORPHOLINOACETYL-2-METHYL-3-PHENYL-4-OXO-1, 2, 3, 4-TETRAHYDRO QUINAZOLINE HYDROCHLORIDE (HQ-275)
• RELATIONSHIP OF HQ-275 TO BILIARY EXCRETION AND PORTAL BLOOD FLOW IN DOGS
• EFFECTS OF PSYCHOTROPIC DRUGS ON EMOTIONAL BEHAVIOR: EXPLORATORY BEHAVIOR OF NAIVE RATS IN HOLED OPEN FIELD
• EFFECTS OF 1-MORPHOLINOACETYL-2-METHYL-3-PHENYL-4-OXO-1, 2, 3, 4-TETRAHYDROQUINAZOLINE HYDROCHLORIDE (HQ-275) ON ACUTE EXPERIMENTAL HEPATIC INJURY INDUCED BY CARBON TETRACHLORIDE IN RATS

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