METABOLISM OF PROSTAGLANDIN E<SUB>1</SUB> IN STOMACH, JEJUNUM CHYLE AND PLASMA OF THE DOG AND THE RAT

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概要

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• The metabolic degradation of PGE, was studied by the incubation of <SUP>3</SUP>H-PGE<SUB>1</SUB> with rat and dog plasma and thoracic lymph and the homogenates of various rat and dog tissues. It was observed that rat and dog plasma metabolize very little PGE<SUB>1</SUB> even when incubated for one hr. Very little metabolic degradation of PGE<SUB>1</SUB> was found by dog thoracic lymph. In contrast, rat and dog lung and kidney metabolize PGE<SUB>1</SUB> very rapidly, and approx. 95% of PGE<SUB>1</SUB> was converted to a less polar metabolite within 20 min of incubation. The metabolic degradation of PGE, was also rapid in the homogenates of rat stomach and jejunum, but the velocity of this reaction in these homogenates was slower than that in the rat or dog lung and kidney homogenates.

• 社団法人 日本薬理学会の論文

著者

• Nakano Jiro

  Department Of Medicine And The Laboratory Of Experimental Cardiology St. Louis University School Of

• PRANCAN Arthur

  The U.S. Public Health Service Cardiovascular Physiology and Pharmacology Training Grant

• MORSY Nemat

  Departments of Pharmacology, Medicine and Physiology, University of Oklahoma School of Medicine

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