STUDIES ON MONOAMINE OXIDASE (REPORT 17) EFFECTS OF NaNO<SUB>2</SUB> ON MAO FROM RAT LIVER MITOCHONDRIA
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There have been few reports on monoamine oxidase (MAO) [EC 1.4.3.4. monoamine: oxygen oxidoreductase (deaminating)] activators and at present it is only known that reserpine (1-3), in vivo and 4-diazo-imidazole-5-carboxamide (4), in vitro cause increase in MAO activity.<BR> A previous report from this laboratory showed that sodium nitrite (NaNO<SUB>2</SUB>) activated MAO with certain substrates (5). Namely, using benzylamine, butylamine, amylamine, hexylamine or β-phenylethylamine as substrate, MAO activity in rat liver mitochondria was increased by NaNO<SUB>2</SUB>, while when using tyramine or serotonin it was inhibited. In rat brain mitochondria, MAO activity was increased by NaNO<SUB>2</SUB> when tyramine or butylamine were used as substrates, however, it was inhibited when other substrates were used. These results suggested the presence of multiple forms of MAO in mitochondria.<BR> This paper describes the effects of NaNO<SUB>2</SUB> on the substrate specificities, pS maxima, pH optima and Michaelis constants of MAO in rat liver mitochondria.