EFFECTS OF THIOCYANATE AND ACETYLSALICYLIC ACID ON THE GASTRIC MUCOSAL BARRIER IN RATS

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The proposed presence of the gastric mucosal barrier system, which interferes with the back diffusion of hydrogen ion secreted in gastric juice (1), has been postulated to protect the possible occurrence of mucosal damage due to hydrochloric acid (2). Though the precise nature of the barrier remains biochemically unknown, mucous substances covering the mucous layer or mucosal epithelical cells are indicated to be related with barrier function (3).<BR> Occurrence of the back diffusion of hydrogen ion in association with the equivalent increase in the intraluminal efflux of sodium ion in the surgically or pharmacologically vagotomized stomach of the rat or the dog indicated the equilibrated exchanges of hydrogen and sodium ions across the mucous epithels (4, 5).<BR> Increase in the back diffusion of hydrogen ion by thiocyanate (2) and acetazolamide (6) in the vagotomized dog stomach suggests an essential role of a carbonic anhydrase in the maintenance of the gastric mucosal barrier, as the enzyme is present in the gastric mucosa and activity is inhibited by both agents.<BR> Though thiocyanate as one of non-anticholinergic antacids has been an available pharmacological tool for elucidation of the mechanism of gastric acid secretion, especially in the gastric mucosa of frog in vitro, many discussions have been presented on the mode of its action (7-9).<BR> Marked inhibition of the gastric acid secretion without affecting the volume of gastric juice by thiocyanate in the oral route prompted the study of the correlation between the inhibitory effect and increase in the back diffusion of hydrogen ion by thiocyanate.
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EFFECTS OF THIOCYANATE AND ACETYLSALICYLIC ACID ON THE GASTRIC MUCOSAL BARRIER IN RATS

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