MEASUREMENT OF ARTHRITIC PAIN AND EFFECTS OF ANALGESICS IN THE ADJUVANT-TREATED RAT

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Adjuvant-induced arthritis in rat is widely used in laboratories for evaluating of the antirheumatic activity of drugs, since the pathophysiological syndromes in arthritic rats are analogous to those in rheumatoid arthritis patients in many respects, and since the method is simple and gives satisfactory reproducibility of results (1-3). Many reports have dealt with the anti-inflammatory activity of drugs on adjuvant-induced arthritis, but very little study has been done on the analgesic activity of a single dose of drug in arthritic rat. The great reduction of the reaction threshold to a mechanical stimulus in the arthritic foot of the rat prompted us to utilize this hyperesthesia for testing analgesic activity of drug, especially non-narcotic analgesics.<BR> In the present report a simple method for the determination of the pain threshold in arthritic foot is described and the effects of several non-narcotic analgesics, hydrocortisone and morphine are studied.
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