SELECTIVE TOXICITY OF A BACTERIAL PROTEASE PREPARATION FOR THE RAT BEARING ASCITES SARCOMA

概要

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In recent years, some clinical observations and experimental studies with human subjects as well as animals have showed that a bacterial protease preparation “TSP”, which is elaborated by a strain of Serratia, has anti-inflammatory activity (1).<BR> In the course of our present work in which combination therapy of antitumor antibiotics and anti-inflammatory drugs were used, we observed that the rat bearing ascites tumor, especially MTK-sarcoma III, was particularly susceptible to intraperitoneal administration of TSP.<BR> The exact reason for the selective toxicity of TSP for the rat bearing ascites sarcoma remains obscure. However, the results of the present report seem to indicate that the acute toxicity of TSP when administered intraperitoneally may not be the consequence of the formation of toxic metabolites by the interaction between TSP and tumor cells or ascitic fluid in the peritoneal cavity. Conceivably, further studies on this unexpected phenomenon will provide information concerning specific interactions between some protein and the peritoneal membrane and also alterations of the properties of plasma membranes resulting from this malignant tumor.
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