STUDIES ON THE PROMOTING FACTORS OF GALACTOSE AND LACTOSE METABOLISM IN THE WHEY : IV. CONCERNING SUBSTANCES IN WHEY THAT INHIBIT DIARRHEA AND CONSEQUENT TROPHOPATHY DEVELOPED WITH LACTOSE AND GALACTOSE

概要

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It has been long recognized that severe diarrhea, sometimes followed by death, develops in young albino rats and mice because of hyperlactose and hypergalactose diets and that rat cataract also develops. Similar results have been reported by Guha (1). It was described in our previous paper (2, 3) that symptoms resulted from the activity of Leloirs enzyme system being deranged by the excessive lactose and galactose.<BR> On the other hand, Takuma, Takayama (4) Tamura, and their co-workers (5) confirmed the fact that preventive factors inhibiting death due to diarrhea and cataract are contained in whey. It has also been demonstrated in a previous paper that the factors preventing cataract developed in rats fed on a hyperlactose diet were lower neutral saturated fatty acid. However, the factors to prevent death due to diarrhea and nutritional disorder seem to be different from those to inhibit cataract. Accordingly, we conducted studies on this point.