PHARMACOLOGICAL STUDIES OF 5-METHYL-8-ETHYL-SULFONYL-10-(2-DIMETHYLAM INOETHYL)-5H-DIBENZO [B, E] [1, 4] DIAZEPINE-11 (10)-ONE (SM-307), AN ANTIDEPRESS IVE SUBSTANCE
スポンサーリンク
概要
- 論文の詳細を見る
Since the introduction of dibenzepine (Noveril®) in the medical practice, this compound has been used for the management of depression. Stille et al. (1) have suggested that dibenzepine should be placed somewhere between imipramine and desipramine. In our laboratory we were engaged in an investigation on the influence of substitution on the tricyclic group on the biological activities of this type of compounds and found that the new compound, 5-methyl-8-ethylsulfonyl-10-(2-dimethylaminoethyl)-5H-dibenzo [b, e] [1, 4] diazepine-11 (10)-one (SM-307) was as potent as dibenzepine with regard to antagonism of reserpine induced hypothermia and had lower toxicity than dibenzepine. The present report serves to confirm some of the antidepressive effects of SM-307 compared with imipramine and other antidepressive substances.
- 社団法人 日本薬理学会の論文
著者
-
Nose Takashi
Department Of Neurological Surgery Insititute Of Clinical Medicine University Of Tsukuba
-
KOWA Yoshio
Department of Pharmacology, Research and Development Division, Tanabe Seiyaku Co., Ltd.
関連論文
- Dielectric Property of Epitaxial Films of BaTiO_3 Synthesized by Laser Ablation ( FERROELECTRIC MATERIALS AND THEIR APPLICATIONS)
- A COMPARISON OF THE INHIBITORY EFFECTS OF CERTAIN ANTIPARKINSONIAN AGENTS ON DOPAMINE ACCUMULATION INTO THE RAT STRIATUM
- PHARMACOLOGICAL STUDIES OF 5-METHYL-8-ETHYL-SULFONYL-10-(2-DIMETHYLAM INOETHYL)-5H-DIBENZO [B, E] [1, 4] DIAZEPINE-11 (10)-ONE (SM-307), AN ANTIDEPRESS IVE SUBSTANCE
- SUBCELLULAR LOCALIZATION OF DOPAMINE IN THE RAT STRIATUM
- Pharmacological Studies on Cutaneous Inflammation Induced by Ultraviolet Irradiation (1): Quantification of Erythema by Reflectance Colorimetry and Correlation with Cutaneous Blood Flow
- Effects of butorphanol and its metabolites on the levels of monoamines and their metabolites in the rat brain.