AN EXPERIMENTAL STUDY OF THE β-RECEPTOR BLOCKING AGENTS ON THE CARDIAC PERFORMANCE IN DOGS
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概要
- 論文の詳細を見る
Since the introduction of dichloro analogue of isoprenaline (DCI) by Powell and Slatter (1), several β-receptor blocking agents have been introduced in the present day medicine. Among these, propranolol is being used in various clinical conditions like angina pectoris (2-3), myocardial infarction (4) and ventricular arrhythmias (5-6). Further, propranolol has been used as local anaesthetic in minor surgical procedures (7). However, the clinical usefulness of these agents in various cardiac conditions is limited by the fact that they, some times, induce severe and irreversible cardiac failure. The present study has been done on the heart-lung preparation of the dog with a view to assess the relative myocardial depressant activity of INPEA and propranolol and also to find out some suitable agents which may effectively antagonize the cardiac failure caused by these agents.
- 公益社団法人 日本薬理学会の論文
著者
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SINHA J.N.
Department of Pharmacology & Therapeutics, K.G.s. Medical College, Lucknow University
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KOHLI R.P.
Department of Pharmacology & Therapeutics, King Georges Medical College
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BHARGAVA K.P.
Department of Pharmacology & Therapeutics, King Georges Medical College
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KULSHRESTHA V.K.
Department of Pharmacology & Therapeutics, King Georges Medical College
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SINGH N.
Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research
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SRIVASTAVA R.K.
Department of Pharmacology & Therapeutics, King George's Medical College
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SRIVASTAVA R.K.
Department of Pharmacology & Therapeutics, King George's Medical College
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SINHA J.N.
Deparment of Pharmacology and Therapeutics, K.G's Medical College, Lucknow University
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BHARGAVA K.P.
Department of Pharmacology & Therapeutics, King George's Medical College
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KULSHRESTHA V.K.
Department of Pharmacology & Therapeutics, King George's Medical College
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