METABOLIC FATE OF 5-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE (SIN-10) : 1. ABSORPTION, EXCRETION AND TISSUE DISTRIBUTION IN RATS AND MICE

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5-Ethoxycarbonyl-3-morpholinosydnonimine (SIN-10), synthesized by Masuda et al. (1) is one of sydnonimine derivatives with mesoionic ring. Following is its<BR>chemical structure. The pharmacological studies on SIN-10 by Takenaka et al. (2) showed a sustained hypotensive effect in rabbits. The similar effect was also confirmed in the dog, cat and rat by Kikuchi et al. (3). In order to provide a biochemical basis for the pharmacological and toxicological mechanisms, the metabolic aspects of SIN-10 have been studied in rats and mice. The present paper deals with the absorption, excretion and tissue distribution of <SUP>14</SUP>C-labeled SIN-10. The metabolic conversion in the living matters and the identification of the metabolites are reported elsewhere (4).
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