EXPERIMENTAL PULMONARY EDEMA IN RODENTS FOLLOWING A SINGLE INJECTION OF 4-NITROQUINOLINE 1-OXIDE

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概要

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• Administration of 4-nitroquinoline 1-oxide has been known to produce pulmonary tumors in rodents (1-3). An electron microscopic examination on the lung of rats shortly after an injection of this compound revealed induction of nucleolar segregation in the alveolar epithelial cells (4). In this experiment, it was further shown that an injection of 4-nitroquinoline 1-oxide could produce pulmonary edema in rats as well as in guineapigs and rabbits.

• 社団法人 日本薬理学会の論文

著者

• 林 裕造

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 長谷川 紀昭

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 片山 博雄

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 長谷川 紀昭

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

• 片山 博雄

  Shionogi Research Laboratory, Shionogi & Co., Ltd.

関連論文

• STEROID-INDUCED INTRAHEPATIC CHOLESTASIS IN MICE
• EXPERIMENTAL PULMONARY EDEMA IN RODENTS FOLLOWING A SINGLE INJECTION OF 4-NITROQUINOLINE 1-OXIDE

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