THE ACTION OF SYMPATHOMIMETIC AMINES AND A NEW <I>BETA</I>-ADRENERGIC BLOCKING AGENT (4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)-INDOLE) ON THE ISOLATED TRACHEA OF GUINEA PIGS

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概要

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• The report that dichlorisoprenaline, DCI, the first introduced <I>beta</I>-adrenergic receptor blocking agent, could block <I>beta</I>-adrenergic receptors initiated a research for other <I>beta</I>-receptor blocking agents.<BR> Thereafter, several compounds, such as pronethalol [Black and Stephenson (I) ], propranolol [Black <I>et al</I>. (2)], H56/28 [Åblad <I>et al</I>. (3)] and others, have been described as capable of producing more potensive and selective blockade of <I>beta</I>-adrenergic receptor sites.<BR> Recently a new <I>beta</I>-adrenergic receptor antagonist, 4-(2-hydroxy-3-isopropylamino-propoxy)-indole (LB-46) (4), has been introduced. This compound is a basic indole with a side-chain characteristic of <I>beta</I>-adrenergic receptor blocking agents.<BR> Investigation was performed to make clear an antagonistic effect of this compound against isoprenaline, adrenaline and noradrenaline in comparison with the above-men-tioned <I>beta</I>-adrenergic receptor blocking agents.

• 社団法人 日本薬理学会の論文

著者

• 大鳥居 健

  Department of Pharmacology, Niigata University School of Medicine

関連論文

• THE ACTION OF SYMPATHOMIMETIC AMINES AND A NEW BETA-ADRENERGIC BLOCKING AGENT (4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)-INDOLE) ON THE ISOLATED TRACHEA OF GUINEA PIGS
• INTERACTION OF ADRENALINE AND BETA-ADRENERGIC BLOCKING AGENTS ON THE ISOLATED SEMINAL VESICLE OF GUINEA PIGS

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