INHIBITION OF SPINAL POLYSYNAPTIC REFLEX AND AUGMENTATION OF MUSCLE CONTRACTION BY 2-ETHYL-4-ETHYLAMINO-6-METHOXY-S-TRIAZINE

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Our previous observation in the cat with implanted electrodes has demonstrated that 2-ethyl-4-ethylamino-6-methoxy-s-triazine (EEM) induced a long-lasting electroence-phalographic (EEG) activation and tachypnea. While the animal was initially excited as indicated by some restlessness, salivation, defecation and occasionally vocalization, thereafter it showed depressive behaviors such as mild muscular weakness, decreased locomotor activity, decreased responsiveness to extroceptive stimuli and lying prostrate throughout the EEG activation (1). Furthermore, the sympathetic excitement induced by EEM in curarized cat persisted for a considerably long period but always outlasted its EEG change (2). In the rat, this agent produced a cataleptic sign and disrupted the conditioned avoidance behavior without failure of the escape response. Despite activating both the electrical brain activity and the autonomic nervous function in such a manner, the motor function and the conditioned behavior were moderately depressed. Our preceding papers have stressed the important roles of the brain stem for the EEG activation and that of the posterior hypothalamus for the sympathetic excitements.<BR> The present experiments were carried out to study the effect of EEM on spinal reflex and muscle contraction in an attempt to clarify the mechanism of its motor depression.
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