CRITICAL STUDIES OF THE PYLORUS LIGATED RAT (SHAY RAT)

スポンサーリンク

概要

• 論文の詳細を見る

• The pylorus ligated rat (Shay rat) was described by Shay <I>et al</I>. (1) for the production of acute ulcers in the forestomach, and it has been also employed as a means of studying gastric secretion. This technique is now used extensively as a screening method of gastric secretory depressants and antipeptic ulcer agents (2-4) because of the following advantages: <I>1</I>) the simplicity of surgical procedure, <I>2</I>) the high rate and rapid occurrence of ulceration, and <I>3</I>) the possibility of measurements of gastric secretory rate and severity of ulceration in the same animals; which make up for the shortcoming that ulcers are present only in the forestomach.<BR> The pathogenesis of ulceration in the pylorus ligated rat has been discussed by many investigators, but the definite conclusion is not yet offered. Several factors have been considered as causes of ulceration; such as the digestive effect of gastric juice, the interference of blood circulation or the decrease of mucosal resistance. Sun and Chen (5) concluded that the rumenal ulcers in the pylorus ligated rat might be merely a result of the volume and the concentration of gastric hydrochloric acid and pepsin upon the mucosa. But other factors can not be ruled out completely.<BR> There remains some obscurities also in the gastric secretory mechanism of the pylorus ligated rat. It is often said that the pylorus ligated rat is inadequate for the estimation of stimulants of gastric secretion, for they can hardly increase in gastric secretion in response to stimuli owing to the hypersecretion. The mechanism of the hypersecretion in the pylorus ligated rat is now still controversial.<BR> The present study is an attempt to clarify the effects of various factors on gastric secretory rate and ulceration and to discuss the mechanisms of ulceration and gastric hypersecretion in the pylorus ligated rat.

• 公益社団法人 日本薬理学会の論文

著者

• 石井 靖男

  Research Laboratories, Nippon Kayaku Co., Ltd.

関連論文

• PHARMACOLOGICAL ACTIVITIES OF t-AMYLOXY-CARBONYL TRYPTOPHANYL-METHIONYL-ASPARATYL-PHENYLALANINE AMIDE
• MECHANISM OF GASTRIC ANTISECRETORY ACTIVITY OF A NEW FRACTION OF LICORICE ROOT (FM100)
• CRITICAL STUDIES OF THE PYLORUS LIGATED RAT (SHAY RAT)

スポンサーリンク