RENIN SECRETION IN THE PERFUSED DOG KIDNEY

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概要

• 論文の詳細を見る

• In the previous paper (1), the present authors reported a new perfusion method, in which the kidney of a recipient dog with intact innervation was perfused with the donors blood using an artificial heart-lung apparatus. That method revealed a good response of renal vessels to various vasoactive substances as well as good hemodynamic conditions for about one hour, following by a gradual increase of renal vascular resistance. Such an increase in renal vascular resistance of the perfused dog kidney was also observed by several investigators (2-5), who used perfusion methods somewhat different from the authors method. But the mechanism for the increase has been left unclarified. In the present study, it was observed that renin was liberated from the perfused kidney, and angiotensin was produced due to interaction of renin and its substrate in the perfusion circuit. The angiotensin thus formed constricted renal vessels, resulting in an increase in renal vascular resistance.

• 社団法人 日本薬理学会の論文

著者

• 上田 重郎

  Department of Pharmacology, Osaka City University Medical School

• 山木 研二郎

  Department of Pharmacology, Osaka City University, Medical School

• 長谷川 隆通

  Department of Pharmacology, Osaka City University, Medical School

関連論文

• EFFECTS OF DIBUTYRYL CYCLIC 3, 5-ADENOSINE MONOPHOSPHATE ON THE RENAL FUNCTION
• EFFECT OF EXOGENOUS ADENOSINE TRIPHOSPHATE ON THE EXTRUSION AND RETENTION OF ION IN THE KIDNEY CORTEX MITOCHONDRIA
• RELEASE OF RENIN FROM DOG KIDNEY CORTEX SLICES IN VITRO
• RENIN SECRETION IN THE PERFUSED DOG KIDNEY
• A RELEASE OF RENIN FROM DOG KIDNEY CORTEX SLICES
• RENAL CLEARANCE OF CYTOCHROME C IN THE RAT

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