STUDIES ON THE EXPERIMENTAL GASTROINTESTINAL ULCERS PRODUCED BY RESERPINE AND STRESS : I. RELATIONSHIP BETWEEN PRODUCTION OF ULCERS AND CHANGES IN TISSUE MONOAMINES

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概要

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• In recent years a number of methods for producing psychogenic ulceration have been reported. Ulcers could be formed by treatment with reserpine combined with stress such as restraint(l), conflict (2), electrical stimulation of the hypothalamus (3), and electrical shock through a grid in the floor (4). Kido (4) has described production of ulcers in cats by exposure to stress such as electrical or mechanical shock after the tissue monoamines had been exhausted by reserpine treatment. When the stress was given during the release of monoamines by reserpine no ulcer could be formed. This shows that monoamines such as serotonin and norepinephrine are involved in the formation of ulcers. The present paper describes <I>1)</I> the cellular localization of serotonin and norepinephrine in the gastrointestinal tract of cats by the method developed by Carlsson <I>et al</I>. (5, 6), <I>2)</I> correlation between manoamine contents and ulcer and <I>3)</I> the role of stress in the formation of ulcers.

• 社団法人 日本薬理学会の論文

著者

• 堤内 正美

  Division of Neuropharmacology, Shionogi Research Laboratory, Shionogi & Co., Ltd.

関連論文

• STUDIES ON THE EXPERIMENTAL GASTROINTESTINAL ULCERS PRODUCED BY RESERPINE AND STRESS : 3. EFFECTS OF MONOAMINES AND THEIR PRECURSORS
• STUDIES ON THE EXPERIMENTAL GASTROINTESTINAL ULCERS PRODUCED BY RESERPINE AND STRESS : II. ULCEROGENIC ACTIVITIES OF RESERPINE AND ITS ANALOGUES
• HISTOCHEMICAL DEMONSTRATION OF SMALL CELLS CONTAINING CATECHOLAMINE IN THE ADRENERGIC PELVIC GANGLIA OF GUINEA-PIG
• STUDIES ON THE EXPERIMENTAL GASTROINTESTINAL ULCERS PRODUCED BY RESERPINE AND STRESS : I. RELATIONSHIP BETWEEN PRODUCTION OF ULCERS AND CHANGES IN TISSUE MONOAMINES

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