Distribution of S-100 Protein-Positive Dendritic Cells Insidethe Cancer Nest and Expression of HLA-DR Antigen and Blood Group Antigen on the Cancer Cell in Transitional Cell Carcinoma of the Urinary Bladder: In Relation to Tumor Progression and Prognosis.
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The distribution of S-100 protein positive dendritic cells (S100-DCs) inside the cancer nest and the expression of HLA-DRα antigen (HLA-DR) and blood group antigen (BGA) on cancer cells in 90 cases of transitional cell carcinoma (TCC) of the urinary bladder were immunohistochemically investigated in relation to the degree of malignancy and its prognosis.A dense infiltration of S100-DCs inside the cancer nest ("many", i. e. more than 10DCs/HPF) was detected in 47 (52%) out of 90 cases. The HLA-DR positive cancer cells (DR-CCs) were detected in 24 cases (27%), including in the 16 most dense cases ("many", i. e. more than 100DR-CCs/HPF). BGA positive cancer cells (BGA-CCs) were detected in 49 cases (54%) ("positive", i. e. more than 100BGA-CCs/HPF).In connection with the degree of malignancy and with the number of cases affected by S100-DCs infiltration. HLA-DR expression and BGA expression. A statistical analysis showed significant correlation between the number of cases affected by S100-DC and each clinicopathological factor including G, pT, ly, v, and showed also between that affected by BGA expression and each clinicopathological factor including G, pT, INF, but showed no significant correlation between that affected by HLA-DR and each clinicopathological factor.As regards the prognosis, the 10-year survival rates for all 90 cases were 60.4%. In the 10-year survival rate, S100-DCs "many" (77.7%) and "few" (39.0%), DR-CCs "many" (85.7%) and "no" (56.9%), DR-CCs "many" and "few" (43.8%), BGA-CCs "positive" (74.3%) and BGA-CCs "negative" (46.5%) were statistically significant.A multivariate analysis using Cox's proportional hazards model demonstrated that the most important factor affecting survival was the distance to the organ and lymph node metastasis (m+n), the number of cases affected by S100-DCs, BGA-CCs and DR-CCs in this order and these were statistically significant.These results suggest that S100-DCs, DR-CCs and BGA-CCs may play a role independently as a prognostic factor which is to prevent tumor growth.
- 社団法人 日本泌尿器科学会の論文
社団法人 日本泌尿器科学会 | 論文
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