Objective and Subjective Response in Stage D2 Prostate Cancer Patients with Cancer Pain.
スポンサーリンク
概要
- 論文の詳細を見る
Fourty-eight patients with stage D2 prostate cancer, initially treated with endocrine therapy at the University of Tokyo between 1981 and 1990, were followed up and analysed. For the assessment of a subjective response, pain score, narcotic score, and performance stages (PS) were used.Of the fourty-eight patients, twenty-one suffered from cancer pain due to bone metastases. These patients showed significantly (p<0.01) more lesions of bone metastases and higher PS, compared with patients without cancer pain. The progression free servival of these patients was significantly (p<0.01) lower than that of patients without cancer pain, although the actuarial survival was not significant.In twenty-one patients with cancer pain, the objective and subjective response rates to endocrine therapy were 75% and 86%, respectively. The duration of pain relief was 1.25-54 (median 19) months. Those rates to anti-cancer chemotherapy in refractory patients (8 patients) previously treated with endocrine therapy were both 25%, and those to additional administration of flutamide (FUL) or diethylstilbestrol (DES) in refractory patients (6 patients) were 33% and 100%, respectively. Although the duration of pain relief was 0.78-8 (median 2) months, the additional administration of DES or FLU led to pain relief and improved quality of life (QOL) in all 6 patients.Endocrine therapy such as LH-RH agonist and non-steroidal pure anti-androgen, which has no severe side effects, would be of great usefulness in stage D2 prostatic cancer patients with pain on the basis of efficacy and safety. An additional administration of DES or FLU in hormone-refractory patients might be effective for the relief of cancer pain and improvement of QOL, although the duration of pain relief was not so long.
- 社団法人 日本泌尿器科学会の論文
社団法人 日本泌尿器科学会 | 論文
- Gastrocytoplasty in Pediatric Patients: Initial Clinical Experience with 5 Cases.:Initial Clinical Experience with 5 Cases
- Tumor Heterogeneity in DNA Ploidy of Renal Cell Carcinomas as Revealed by Static Cytofluorometry and Flow Cytometry.
- Objective and Subjective Response in Stage D2 Prostate Cancer Patients with Cancer Pain.
- A Case of Testicular Tumor with a Small Tumor Focus in the Testis.
- Trans-Duodenal-Recess Laparoscopic Nephrectomy and Adrenalectomy: Preliminary Report.:Preliminary Report