膀胱移行上皮癌に対する Bacillus Calmette-Guerin の免疫学的作用機序の研究-血清および尿中のTNF-α, IL-2の変動について-

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To study the mechanism of action of BCG against transitional cell carcinoma of the bladder from the immunological standpoint, we observed time-course changes in the serum and urine levels of tumor necrosis factor (TNF-α) and interleukin-2 (IL-2) before and after an intravesical BCG instillation in 16 patients with superficialis transitional cell carcinoma. Serum TNF-α concentrations were roughly constant and lower than normal though there was a slight difference between the values before and after BCG instillation or between the test and control values. TNF-α secretion in urine was increased irrespectine of the time for sampling specimens as compared with the control values sampling, remained unaffected by BCG installations and was increased in many patients even before BCG instillation, probably due to presence of vesical inflammation. No significant changes were detected regarding serum or urine IL-2 before and after BCG instillation and between the test and control values. Thus, the present study failed to demonstrate the involvement of a direct action of TNF-α, activation of immunological cells by IL-2 or its direct action as an anti-tumor effect of intravesical instillation of BCG.
社団法人日本泌尿器科学会の論文