PHARMACOLOGICAL PROPERTIES OF 3-(<I>p</I>-CHLOROBENZYL) QUINOLIZIDINE TARTARATE (QB-1), A NEW OXYTOCIC

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概要

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• On the pharmacological investigation of quinolizidine derivatives, it was discovered that one of them had marked oxytocic activity. The chemical struture of this compound [3-(<I>p</I>-chlorobenzyl) quinolizidine tartarate; QB-1] is as follows: This compound was synthesized by Matsuo <I>et al</I>. (1). It is a colorless crystal consisting of two isomers, isomer A (m.p. 98-103°C) and isomer B (m.p. 93-96°C). The ratio of isomer A to isomer B is 6: 4. The present paper describes oxytocic activity of QB-1 together with other pharmacological properties.

• 公益社団法人 日本薬理学会の論文

著者

• 塩屋 明利

  Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., L

• 高野 昇

  Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• 田村 正昭

  Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.

• 永島 廉平

  Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.

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