EFFECT OF SALICYLATES ON VASCULAR RESPONSES

スポンサーリンク

概要

• 論文の詳細を見る

• Strom and Coffman (1) found that aspirin produced a significant reduction in peripheral blood flow responses to i.v. epinephrine and nor-epinephrine in human beings. Hashimoto <I>et al</I>. (2) studied the effect of sodium salicylate on reflex vascular responses to dimethylamino prophy-tetrahydro-azaazepino phenothiazine (RPP201), andromedotoxin, veratridine, bradykinin and kallikrein injected in the femoral or renal artery of the isolated hindlimb or kidney preparation perfused by cross-circulation. Sodium salicylate abolished completely the pressor response to RPP201, andromedotoxin, veratridine, bradykinin or kallikrein. The depressor response to the last two agents was, however, unaffected. Anticholinergic, antiadrenergic, antihistaminic, antiserotonin and neuromuscular or ganglion-blocking agents did not influence the reflex vascular response. Since salicylates are used as anti-inflamatory and anti-rheumatic agents, an action on the blood vessels may be of significance in the mechanism of this effect. Hence it was thought of interest to study the effect of salicylates on responses to certain other pressor and depressor agents. The results obtained are reported in this communication. A preliminary report of the work has been presented [Ahmad and Dhawan (3)].

• 公益社団法人 日本薬理学会の論文

著者

• DHAWAN B.N.

  Department of Pharmacology, College of Veterinary Science, Jabalpur and Central Drug Research Inst.

• Ahmad A.

  Department Of Entomology University Of Agriculture Faisalabad

• DHAWAN B.N.

  Department of Pharmacology, M.L.N. Medical College

関連論文

• Provenance and weathering history of Archaean Naharmagra quartzite of Aravalli craton, NW Indian shield : Petrographic and geochemical evidence
• Consumption and Coefficient of Utilization of Different Host Plants by Mythimna separata Walk
• METRAZOL TEST FOR RAPID SCREENING OF ANTICONVULSANTS
• EFFECT OF SALICYLATES ON VASCULAR RESPONSES

スポンサーリンク