ANALYSIS OF THE INOTROPIC ACTION OF THIAMINE TETRAHYDROFURFURYL DISULFIDE ON THE ISOLATED ATRIA OF THE GUINEA PIG

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The author (1) previously reported that thiamine alkyl disulfides such as tetrahydrofurfuryl and propyl derivatives of thiamine, exerted a positive inotropic and negative chronotropic effects on the isolated, spontaneously beating atria of the guinea pig. Nakazawa and Ueno (2) pointed out that thiamine alkyl disulfides produced a positive inotropic action by a hitherto unknown mechanism. The importance of the relation of the time interval between contractions to the strength of contraction of heart muscle was supported in the numerous papers discussed in a review by Koch-Weser and Blinks (13). It was also demonstrated (4-10) that the drugs with inotropic effects on the heart, modified the interval-strength relationship of heart muscle. Kruta (11) pointed out that the interval-strength relationship gives a clue for the understanding of the mechanism of inotropic action of drugs. The present studies were undertaken to analyze the positive inotropic effect of thiamine alkyl disulfides with particular emphasis on the effect of the drug on the frequency-tension relationship (4, 8, 12), post-stimulation potentiation (13) and post-extrasystolic potentiation (14, 15) which are encompassed in the interval-strength relationship.
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