THE BLOCKING ACTION OF PRONETHALOL ON THE CONTRACTION OF ISOLATED SPLEEN STRIPS PRODUCED BY ADRENALINE, ACETYLCHOLINE OR ISOPROTERENOL

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概要

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• It has been reported that spleen strips contract with an addition of adrenaline (13), noradrenaline (3), acetylcholine (1-3), histamine (1-2) or 5-hydroxytryptamine (2) to the bath medium. The adrenaline-induced contraction of the spleen strips can be blocked by alpha-adrenergic blocking agents (1-4). According to Bickerton (4), isoproterenol, which stimulates beta-adrenergic receptors, also contracts the spleen strips and the isoproterenol-induced contraction is specifically blocked by a beta-adrenergic blocking agent, dichloroisoproterenol (5).<BR> The present paper describes that pronethalol, one of the beta-adrenergic blocking agents originally reported by Black and Stephenson (6), inhibits the contraction of spleen strips produced by adrenaline, acetylcholine or isoproterenol, in different species of animals.

• 公益社団法人 日本薬理学会の論文

著者

• 安孫子 保

  Department of Pharmacology, Fukushima Medical College

• 木崎 静子

  Department of Pharmacology, Fukushima Medical College

関連論文

• BLOCKADE WITH DICHLOROISOPROTERENOL (DCI) OF THE SYMPATHETIC FACTOR OF STROSPESIDE INDUCED BRADYCARDIA IN CATS
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• THE BLOCKING ACTION OF PRONETHALOL ON THE CONTRACTION OF ISOLATED SPLEEN STRIPS PRODUCED BY ADRENALINE, ACETYLCHOLINE OR ISOPROTERENOL
• BLOCKADE WITH PROPRANOLOL OF THE POSITIVE INOTROPIC ACTION OF SEROTONIN IN THE DOG

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