THE EFFECT OF CARBON TETRACHLORIDE ON PLASMA CORTICOSTERONE LEVEL

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概要

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• Carbon tetrachloride (CCl<SUB>4</SUB>) as well as chloroform (CHCl<SUB>3</SUB>), which is chlorinated hydrocarbon, has been well known to induce liver damage. CHCl<SUB>3</SUB> however has been used as an anesthetic. CCl<SUB>4</SUB> likewise acts directly on the central nervous system and has a narcotic effect even though the potency is considerably weaker than that of CHCl<SUB>3</SUB> (1).<BR> It was reported that CHCl3 induced a reduction of ascorbic acid in the adrenal glands (2). This observation might imply an activation of the hypophyseo-adrenal axis by CHCl<SUB>3</SUB>.<BR> On the other hand, Brody <I>et al</I>. observed a decrease of catecholamine contents in the adrenal glands and an increase in the plasma and urine following administration of CCl<SUB>4</SUB> (3, 4). So they have assumed that CCl<SUB>4</SUB> acts directly on the hypothalamus and stimulates catecholamine release from the sympathetic nerve and the adrenal glands, and this phenomenon might be involved in the mechanism of CCl<SUB>4</SUB>-induced toxicity.<BR> From these facts, it can be presumed that CCl<SUB>4</SUB> acts directly on the hypothalamus and stimulates a release of corticotropin releasing factor from the hypothalamus and of adrenocorticotropic hormone (ACTH) from the pituitary gland. Consequently the plasma concentration of adrenocortical hormone might be increased.

• 公益社団法人 日本薬理学会の論文

著者

• 古川 達雄

  Department of Pharmacology, Kurume University School of Medicine

関連論文

• THE COUNTERACTION AGAINST THE DEXAMETHASONE-INDUCED ADRENAL INHIBITION BY COLD STRESS
• EFFECT OF HISTAMINE ON MICROCIRCULATION AND INFLUENCE OF DIPHENHYDRAMINE ON THAT
• THE EFFECT OF CARBON TETRACHLORIDE ON PLASMA CORTICOSTERONE LEVEL

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