LINOLEIC ACID COMPONENT IN THE HYPERLIPIDEMIA INDUCED BY TRITON

概要

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Many reports have been published on the genesis of hyperlipidemia induced by parenterally administered Triton WR-1339 (Oxyethylated tertiary octylphenol formaldehyde polymer, Winthrop Laboratories, New York), one of the surface-active agents, but the interests were paid especially on hypercholesterolemia (1-10). Frantz et al. (2) and Hirsch et al. (3) described an enhanced rate of hepatic synthesis of cholesterol as the causal factor for the rise of plasma cholesterol level after Triton injection. As an evidence of enhanced cholesterogenesis, further, Hirsch et al. (4) recognized an increase of body total cholesterol could be induced by Triton in mice without any exogenous sources. Meanwhile, Friedman et al. (6) considered the mobilization of cholesterol from body pool was the primary response in this hypercholesterolemia. At present it is a problem to be solved to determine the origin of plasma excess triglyceride after Triton injection, since this change is greater than that of cholesterol itself and the elevation of plasma cholesterol induced by sustained hypertriglyceridemia has been shown by Friedman et al. (5, 6). The authors in this paper studied on the origin of this plasma excess triglyceride with the use of gaschromatographical analysis of fatty acid composition.
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