STRUCTURE AND ACTIVITY RELATIONSHIP OF MONOAMINE OXIDASE INHIBITORS, PHENYLACETYLHYDRAZIDE DERIVATIVES

スポンサーリンク

概要

• 論文の詳細を見る

• Since the introduction of iproniazid, originally synthesized as antitubercular drug, monoamine oxidase (MAO) inhibitors have been applied to the treatment of mental depression and angina pectoris. Most of the MAO inhibitors are chemically hydrazine and hydrazide derivatives. It is suggested by many investigators that pharmacological effects of the inhibitors derive from accumulation of serotonin and catecholamines in the central nervous system and other organs. The socalled side effects of the inhibitors such as liver damage are supposed to be due to unknown direct effects. Efforts to find out less toxic inhibitors have been done, thereupon.<BR> The present paper describes the structure-activity relationship of new MAO inhibitors, phenylacetylhydrazide derivatives by use of iproniazid and phenylisopropylhydrazine (JB-516) as control. The chemical structures of the derivatives are shown in Fig. 1.

• 公益社団法人 日本薬理学会の論文

著者

• 中村 圭二

  Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories

• 増田 義信

  Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories

• 藤本 克郎

  Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories

• 辰己 煕

  Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories

関連論文

• THE ANTICONVULSANT ACTIVITY OF ETHYL α-PHENYLBUTYROYL ALLOPHANATE (P-5257)
• STRUCTURE AND ACTIVITY RELATIONSHIP OF MONOAMINE OXIDASE INHIBITORS, PHENYLACETYLHYDRAZIDE DERIVATIVES

スポンサーリンク