THE DEPLETION OF CATECHOLAMINE OF THE RABBIT'S ATRIA BY RESERPINE <I>IN VITRO</I>

スポンサーリンク

概要

• 論文の詳細を見る

• The depletion of serotonin and catecholamine from the tissues by reserpine <I>in vivo</I> and <I>in vitro</I> has been confirmed by many authors. The release of catecholamine from the hearts of various mammals <I>in vivo</I> by reserpine was already shown by Bertler <I>et al</I>. (1), Paasonen and Krayer (2), Waud <I>et al</I>. (3). Carlsson <I>et al</I>. (4), reported that the intravenous administration of 5 to 10 μg/kg of reserpine in rabbit decreased the content of heart catecholamine (<I>nor</I>adrenaline) significantly, while the same procedure did not affect the content of brain catecholamine. The .sim.ilar results were also obtained by Orlans <I>et al</I>. (5). Higuchi <I>et al</I>. (6, 7) in this laboratory showed that the depletion of catecholamine in the heart of rabbit which had been injected 0.1 to 1.0 mg/kg of reserpine 24 hours before, was about 90% of the normal content.<BR> Tachi (8) in this laboratory has found that the administration of 10<SUP>-6</SUP> of reserpine to the atrial preparation of rabbit revealed negative chronotropic and inotropic actions, and that the same procedure of above 10<SUP>-5</SUP> of reserpine abolished the rhythmic contraction of the preparation within 60 to 120 minutes after the administration of the drug. Toda (9) in this laboratory has studied the effects of reserpine on the transmembrane potential of the pacemaker and non-pacemaker fibers of the extirpated rabbit's atrium, and also showed that reserpine in the concentration of above 10<SUP>-5</SUP> depressed the potential and at last abolished it. Further, they (Tachi, Toda) have showed that although the replacement of reserpine-Ringer solution in the organ bath with normal Ringer solution did not restart the rhythmic contraction of the auricle and the rhythmic changes of the pacemaker and non-pacemaker potentials, both rhythmic patterns of the atria recovered in response to definite doses of adrenaline or <I>nor</I>adrenaline. From the results it is suggested that the catecholamine which is subjected to release by reserpine might have a determining role in the initiation and maintenance of rhythmic contraction of the heart.<BR> Pepeu <I>et al</I>. (10) studied the effect of reserpine on the catecholamine content in the extirpated guinea pig's heart, suspended in Tyrode-bicarbonate solution, and found some decrease of catecholamine at 6 hours after the administration of 10<SUP>-5</SUP> of reserpine.<BR> In the present experiment the effects of reserpine, iproniazid, and SKF 385 have been studied. It has been expected that the depressive effect of reserpine on the rhythmic contraction of the preparation might have some correlation with the depletion of the catecholamine,

• 公益社団法人 日本薬理学会の論文

著者

• Matsuo T.

  Department Of Pathology Nagasaki University School Of Medicine

• MATSUO TAKAAKI

  Department of Pharmacology, Faculty of, Medicine, Kyoto University

関連論文

• Distribution of cell surface substances and extracellular matrices in the developing rat heart : Abstracts of Papers Presented at the Thirty-Third Annual Meeting of the Japanese Teratology Society Nagoya, Japan, July 21-23, 1993
• The distribution of acetylcholinesterase-positive cells in rat embryonic hearts with special reference to the relationship with the conduction system : Abstracts of Papers Presented at the Thirty-Third Annual Meeting of the Japanese Teratology Society Nag
• Extracellular matrix and epithelial cell in hypoplastic fetal rat thymus induced by bis-diamine : Abstracts of Papers Presented at the Thirty-Second Annual Meeting of the Japanese Teratology Society Tokyo, Japan, July 8-10, 1992
• Immunoelectron microscopic localization of HNK-1 in the embryonic rat hear with special reference to the development of the conduction system : Abstracts of Papers Presented at the Thirty-Second Annual Meeting of the Japanese Teratology Society Tokyo, Jap
• Expression of Leu-7, Leu-11 and N-CAM in embryonic rat hearts : Abstracts of Papers Presented at the Thirty-First Annual Meeting of the Japanese Teratology Society Izumo, Japan, July 11-12, 1991
• Three-dimensional reconstruction analysis of the conduction system in bis-diamine-induced malformed rat heart, using computer graphics : Abstracts of Papers Presented at the of the Japanese Teratology Society Izumo, Japan, July 11-12, 1991
• The distribution of tenascin in the heart and great vessels with anomalies induced by bis-diamine : Abstracts of Papers Presented at the Thirty-First Annual Meeting of the Japanese Teratology Society Izumo, Japan, July 11-12, 1991
• An autopsy case of laryngeal atresia, esophageal atresia with tracheo-esophageal fistula and duodenal atresia : Abstracts of Papers Presented at the Thirtieth Annual Meeting of the Japanese Teratology Society Miyazaki, Japan, July 12-13, 1990
• An autopsy case of multiple anomalies in the urogenital system with atresia of larynx, esophagus and duodenum : Abstracts of Papers Presented at the Thirtieth Annual Meeting of the Japanese Teratology Society Miyazaki, Japan, July 12-13, 1990
• The distribution of tenascin, fibronectin and Leu-7 in the rat embryo heart : Abstracts of Papers Presented at the Thirtieth Annual Meeting of the Japanese Teratology Society Miyazaki, Japan, July 12-13, 1990
• An autopsy case of thanatophoric dysplasia with holoprosencephaly : Abstracts of Papers Presented at the 29th Annual Meeting of the Japanese Teratology Society, Yamagata, Japan July 13 - 14
• Development of the conduction system in human and rat hearts : Abstracts of Papers Presented at the 29th Annual Meeting of the Japanese Teratology Society, Yamagata, Japan July 13 - 14
• The conduction system of rats with anomalies of the heart and the great arteries induced by bis-diamine : Abstracts of Papers Presented at the 29th Annual Meeting of the Japanese Teratology Society, Yamagata, Japan July 13 - 14
• An operative case of occipital meningoencephalocele : ABSTRACTS OF PAPERS PRESENTED at the TWENTY-SEVENTH ANNUAL MEETING of the JAPANESE TERATOLOGY SOCIETY TOKYO, JAPAN, JULY 17-18, 1987
• Immunohistochemical analysis of the developmental mechanism of cardiovascular anomalies induced by bis-diamine : ABSTRACTS OF PAPERS PRESENTED at the TWENTY-SEVENTH ANNUAL MEETING of the JAPANESE TERATOLOGY SOCIETY TOKYO, JAPAN, JULY 17-18, 1987
• Computer-Assisted Total Material Design of Woven Fabrics for Apparel Use Part 3 : Methods for Determining Priority, Suitability, Conceptual Design Phase and Related Application Examples
• A-21 Expression of IL-1α in neuroepithelium of exencephaly induced by retinoic acid in mice.
• P-126 Disturbances in Spermatogenesis of Rats Exposed to Bisphenol A in utero.
• Distribution of BNK-1 in bisdiamine induced malformed embryonic rat heart : Abstracts of Papers Presented at the Thirty-Fourth Annual Meeting of the Japanese Teratology Society Kochi, Japan July14-16, 1994
• P-55 Dietary Docosahexaenoic Acid Intake during Gestation and Lactation Period and the Preweaning Reflex Development of Wistar Rats.
• Dietary Docosahexaenoic Acid Intake during Gestation and Lactation Period and the Preweaning Reflex Development of the Stroke-Prone Spontaneously Hypertensive Rat : Poster Sessions
• Effects of reserpine on the reproduction and development of the spontaneously hypertensive rat (SBR) : Abstracts of Papers Presented at the Thirty-Fourth Annual Meeting of the Japanese Teratology Society Kochi, Japan July14-16, 1994
• The effects of neonatal administration of vitamin A on behaviors and functions in Wistar rats : Abstracts of Papers Presented at the Thirty-Second Annual Meeting of the Japanese Teratology Society Tokyo, Japan, July 8-10, 1992
• Reduced level of basic fibroblast growth factor in yolk sac by retinoic acid induced embryonic death : Abstracts of Papers Presented at the Thirty-First Annual Meeting of the Japanese Teratology Society Izumo, Japan, July 11-12, 1991
• Effects of caffeine on the myoblasts of Xenopus larvae : Abstracts of Papers Presented at the Thirtieth Annual Meeting of the Japanese Teratology Society Miyazaki, Japan, July 12-13, 1990
• Association of spina bifida with tail anomalies in mouse embryos after retinoic acid exposure in utero : Abstracts of Papers Presented at the Thirtieth Annual Meeting of the Japanese Teratology Society Miyazaki, Japan, July 12-13, 1990
• Lead-induced developmental lesions in the central nervous system of the chick embryo : ABSTRACTS OF PAPERS PRESENTED at the TWENTY-SEVENTH ANNUAL MEETING of the JAPANESE TERATOLOGY SOCIETY TOKYO, JAPAN, JULY 17-18, 1987
• Evaluation of the Xenopus laevis embryo system for the assessment of developmental toxicity of environmental chemicals: ABSTRACTS OF PAPERS PRESENTED at the TWENTY-SEVENTH ANNUAL MEETING of the JAPANESE TERATOLOGY SOCIETY TOKYO, JAPAN, JULY 17-18, 1987
• Effect of retinoic acid on migrating neural crest cells : ABSTRACTS OF PAPERS PRESENTED at the TWENTY-SEVENTH ANNUAL MEETING of the JAPANESE TERATOLOGY SOCIETY TOKYO, JAPAN, JULY 17-18, 1987
• Roles of TLR2, TLR4, NOD2, and NOD1 in Pulp Fibroblasts
• Caries-related Bacteria and Cytokines Induce CXCL10 in Dental Pulp
• Atomic Bomb and Leukemia
• Survey on the bioethics of congenital anomalies in medical students : Abstracts of Papers Presented at the Thirtieth Annual Meeting of the Japanese Teratology Society Miyazaki, Japan, July 12-13, 1990
• Phase Equilibria and Phase Transformation of Ti-Al-M Ternary Systems at Elevated Temperatures
• Maldevelopment of Vascular System in Mouse Embryos Exposed to Retinoic Acid in utero : Paper Presented from Platform
• Abnormal brain development induced by reduction of erythropoietin in early postimplantation mouse embryos : Papers Presented from Platform
• Erythropoietin in mouse embryos with unfused neural tube after exposure to retinoic acid : The 35th Annual Meeting of the Japanese Teratology Society
• Defect of umbilical vessels of mouse embryos exposed to retinoic acid in utero : Abstracts of Papers Presented at the Thirty-Fourth Annual Meeting of the Japanese Teratology Society Kochi, Japan July14-16, 1994
• Analysis of embryos with avascular yolk sac induced by retinoic acid in mice : Abstracts of Papers Presented at the Thirty-Third Annual Meeting of the Japanese Teratology Society Nagoya, Japan, July 21-23, 1993
• Protamine disturbs development of vitelline blood vessels in mice : Abstracts of Papers Presented at the Thirty-Second Annual Meeting of the Japanese Teratology Society Tokyo, Japan, July 8-10, 1992
• Acceleration of gonocyte differentiation in fetal mice exposed to retinoic acid prenatally : Abstracts of Papers Presented at the 29th Annual Meeting of the Japanese Teratology Society, Yamagata, Japan July 13 - 14
• Two cases of 17p-syndrome with hypoplasia of vermis cerebelli : Abstracts of Papers Presented at the 29th Annual Meeting of the Japanese Teratology Society, Yamagata, Japan July 13 - 14
• Deletion screening of dystrophin gene in 94 patients with Duchenne muscular dystrophy (DMD) detected by polymerase chain reaction : Abstracts of Papers Presented at the Thirtieth Annual Meeting of the Japanese Teratology Society Miyazaki, Japan, July 12-1
• THE DEPLETION OF CATECHOLAMINE OF THE RABBIT'S ATRIA BY RESERPINE IN VITRO
• MPC-Polymer Reduces Adherence and Biofilm Formation by Oral Bacteria

もっと見る 閉じる

スポンサーリンク