THE ALDOSTERONE BLOCKING EFFECTS OF SPIROLACTONES
スポンサーリンク
概要
- 論文の詳細を見る
The possibility that a salt regulating hormone played a causative role in the production of edema was developed from the early reports of several investigators. Various authors were able to obtain urinary extracts with good sodium retaining effects from edematous patients with congestive heart failure, nephrosis, or cirrhosis of the liver (<I>cf</I>. 1-4). Simpson, Tait, and Bush (5) discovered the steroid aldosterone in 1952, and in 1954 the sodium retaining factor in the urine of edematous patients was identified as aldosterone by Luetscher and coworkers (6, 7).<BR> In view of the probable role that aldosterone played in the production and maintenance of edema we then asked the question "Would compounds with an aldosterone-blocking activity be effective in relieving edema?". There was an excellent chance that such a relationship would exist and experiments were begun in 1954 by Dr. C. M. Kagawa to study the effects of salt retaining steroids so as to reliably determine their effect. on electrolyte excretion in experimental animals. These investigations were followed by an evaluation of structurally related steroids to determine whether or not they would block the electrolyte effects of the mineralocorticoids. Such studies led to the development of new steroids, the spirolactones, which are capable of blocking the salt retaining effects of desoxycorticosterone and aldosterone in laboratory animals and of producing a diuresis in patients with edema. The properties of the spirolactones, particularly Aldactone, will be discussed.
- 公益社団法人 日本薬理学会の論文