THE INFLUENCE OF MORPHINE AND PHENOBARBITAL ON THE BLOOD CONTENT OF ACETONE-BODIES IN NORMAL RABBITS

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It is led to the effect that it makes a correlation between physiological change of function and intermediary substance of metabolism, such as acetonuria in case of hunger, increase of pyruvic acid and lactic acid in blood of diabetics as well as avitaminostic stage, and such, which had been made public in effect.<BR> Acute chloroform poisoning (1) and that of many narcotics injure the function of liver and kidney and it was shown by many academic reports of the past that it produces considerable changes in intermediary metabolism. While, Quastel and Wheatly (2) have explained that narcotics inhibit the cerebral cells' oxidation by which a special effect brings about on the various functions. Such being the case, narcotics of each kind are considered to be much correlated in point of the intermediary run of metabolism.<BR> I tried, therefore, to examine the amount of lactic acid, an intermediate of carbohydrate metabolism, together with acetone, acetoacetic acid and β-hydroxybutyric acid in blood of rabbits, those of fat metabolim, in order to let me know the physiological change of function by giving morphine hydrochloride and soluble phenobarbital.
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