EFFECT OF [Asu<SUP>1, 7</SUP>]-EEL CALCITONIN AND ITS FRAGMENTS ON GASTRIC ACID SECRETION IN RATS

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概要

• 論文の詳細を見る

• Effect of [Asu<SUP>1, 7</SUP>]-eel calcitonin ([Asu<SUP>1, 7</SUP>]-E-CT), an analogue of natural eel calcitonin, and its fragments on gastric acid secretion was studied in pylorus-ligated rats. [Asu<SUP>1, 7</SUP>]-E-CT markedly reduced the acid secretion with intravenous and intramuscular doses of 3 Medical Research Council units (MRC U)/kg or 0.6 μg/kg. This activity was comparable to that of salmon calcitonin and porcine calcitonin compared with equivalent hypocalcemic doses and was consistently evident during daily administrations for 10 days. Assay of six fragments of [Asu<SUP>1, 7</SUP>]-E-CT showed that the C-terminal peptide consisting of 22 amino acids diminished the acid secretion but shorter peptides of the C-terminal fragment or the Nterminal fragments did not. These results suggest that the C-terminal peptide may play an important role in this action of [Asu<SUP>1, 7</SUP>]-E-CT, and a peptide chain of over 18 amino acids is required.

• 社団法人 日本薬理学会の論文

著者

• Ohno Hiroshi

  Division Of Immunobiology Graduate School Of Nanobioscience Yokohama City University

• TAKAYANAGI Noriyasu

  Division of Pharmacology, Research Laboratories, Toyo Jozo Co., Ltd.

• HAYANO Kazuo

  Division of Pharmacology, Research Laboratories, Toyo Jozo Co., Ltd.

• OHNO Hiroshi

  Division of Pharmacology, Research Laboratories, Toyo Jozo Co., Ltd.

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• EFFECT OF [Asu1, 7]-EEL CALCITONIN AND ITS FRAGMENTS ON GASTRIC ACID SECRETION IN RATS

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