ANTIALLERGIC PROPERTIES OF AN ORALLY EFFECTIVE AGENT, [[3-(1H-TETRAZOL-5-YL)-PHENYL] AMINO] OXOACETIC ACID n-BUTYL ESTER

スポンサーリンク

概要

• 論文の詳細を見る

• A newly synthesized compound, [[3-(1H-tetrazol-5-yl)-phenyl] amino]oxoacetic acid n-butyl ester (MTB) has been demonstrated to be an orally active antiallergic agent. This compound inhibited the 48-hr passive cutaneous anaphylaxis (48-hr PCA) induced by IgE in rats. In guinea pigs, MTB also inhibited the 8-day passive cutaneous anaphylaxis (8-day PCA) and the 8-day passive systemic anaphylaxis induced by IgE. The compound partially inhibited the IgG-mediated 3-hr PCA in rats and guinea pigs, but failed to have any effect on the rabbit IgG-mediated 3-hr PCA in these animals. In the rat, MTB was not an antagonist of histamine or serotonin. The antiallergic effect of MTB was not mediated via any adrenergic mechanisms. MTB significantly inhibited histamine release from rat peritoneal cells induced by rat IgE in vitro.

• 社団法人 日本薬理学会の論文

著者

• AGATA Mitsuji

  Research Institute, Wakamoto Pharmaceutical Co. Ltd.

• GOTO Hiroshi

  Research Institute, Wakamoto Pharmaceutical Co. Ltd.

• TSURIYA Yoshihiro

  Research Institute, Wakamoto Pharmaceutical Co. Ltd.

• TACHIBANA Koichi

  Research Institute, Wakamoto Pharmaceutical Co. Ltd.

• KURODA Toshio

  Research Institute, Wakamoto Pharmaceutical Co. Ltd.

• Agata Mitsuji

  Research Department, Wakamoto Pharmaceutical Co., Ltd.

関連論文

• ANTIALLERGIC PROPERTIES OF AN ORALLY EFFECTIVE AGENT, [[3-(1H-TETRAZOL-5-YL)-PHENYL] AMINO] OXOACETIC ACID n-BUTYL ESTER
• Characterization of a novel aldose reductase inhibitor, TAT, and its effects on streptozotocin-induced diabetic neuropathy in rats.
• A Study of the Biological Pharmacology of IFO, a New Selective and Reversible Monoamine Oxidase-B Inhibitor.

スポンサーリンク