The effects of nifedipine and verapamil on high K+ induced contractions of the rat intestinal tract in vivo.

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概要

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• The effects of intravenous nifedipine and verapamil against the contraction produced by topical application of 54 mM K<SUP>+</SUP> on the outer surface of rat duodenum, jejunum, ileum, caecum, colon and rectum have been investigated. Both drugs exhibited a descending gradient of relaxant activity with the exception of the rectum, verapamil being 1/3-1/4 as potent as nifedipine in all the test systems studied. Since these drugs at effective spasmolytic doses significantly affect heart rate and systemic blood pressure, their use as smooth muscle relaxants in intestinal disturbances would present several drawbacks

• 公益社団法人 日本薬理学会の論文

著者

• MAGGI Carlo

  Pharmacology Department, Research Laboratories, A. Menarini Pharmaceuticals

• Grimaldi Guglielmo

  Pharmacology Department, Research Laboratories, A. Menarini Pharmaceuticals

• Meli Alberto

  Pharmacology Department, Research Laboratories, A. Menarini Pharmaceuticals

• Maggi Carlo

  Pharmacology Department, Menarini Pharmaceuticals

関連論文

• The effects of nifedipine and verapamil on high K+ induced contractions of the rat intestinal tract in vivo.

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