OPPOSITE EFFECTS OF MORPHINE ON FEEDING AND DRINKING IN RATS RELATIVE TO ADMINISTRATION TIME

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概要

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• The present study was undertaken to examine how morphine changes food and water intake in non-fasted or fasted rats with different administration times. Morphine (1, 3 and 10 mg/kg) was intraperitoneally administered at 10:45 (light period) or 18:45 (dark period). Morphine increased food and water intake in non-fasted rats 2 hr after the administration during the light period, whereas the total daily intakes were decreased. In contrast, morphine decreased food and water intake in non-fasted rats during the dark period and in fasted rats during both the light and dark period. These results suggest that morphine disorders the baseline levels of feeding and water drinking of naive rats.

• 社団法人 日本薬理学会の論文

著者

• Kunihara Mineo

  Department Of Pharmacology Japan Upjohn Research Laboratories

• KANBAYASHI Miyuki

  Department of Pharmacology, Japan Upjohn Research Laboratories

• OHSHIMA Takao

  Department of Pharmacology, Japan Upjohn Research Laboratories

関連論文

• MEASUREMENT OF GASTROINTESTINAL TRANSIT OF SOLID FOOD USING A COLESTIPOL-PHENOL RED COMPLEX AS A MARKER
• OPPOSITE EFFECTS OF MORPHINE ON FEEDING AND DRINKING IN RATS RELATIVE TO ADMINISTRATION TIME
• Effects of Spiradoline Mesylate, a Selective .KAPPA.-Opioid-Receptor Agonist, on the Central Dopamine System with Relation to Mouse Locomotor Activity and Analgesia.

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