SELECTIVE BINDING OF YM-09151-2, A NEW POTENT NEUROLEPTIC, TO D<SUB>2</SUB>-DOPAMINERGIC RECEPTORS
スポンサーリンク
概要
- 論文の詳細を見る
Effects of YM-09151-2 and five other neuroleptics (haloperidol, spiperone, chlorpromazine, sulpiride and clozapine) on the binding of [<SUP>3</SUP>H]-ligands to nine different receptors (α<SUB>1</SUB>-adrenergic, α<SUB>2</SUB>-adrenergic, β-adrenergic, muscarinic, D<SUB>2</SUB>-dopaminergic, H<SUB>1</SUB>-histaminergic, 5HT<SUB>1</SUB>-serotonergic, 5HT<SUB>2</SUB>-serotonergic and opiate receptors) and on dopamine-sensitive adenylate cyclase were determined using brain membranes in the rat, guinea-pig and dog. The affinity of YM-09151-2 for D<SUB>2</SUB>-receptors with a K<SUB>i</SUB> value of 0.1 nM was more than 1000-times higher than that for the other receptors and dopamine-sensitive adenylate cyclase, and it was the greatest among the nueroleptics tested.
- 社団法人 日本薬理学会の論文
著者
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TERAI Michio
Department of Pharmacology and Biochemistry, Central Research Laboratories, Yamanouchi Pharmaceutica
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Maeno Hiroo
Department Of Biochemistry Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.
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NOSHIRO OSAMU
Department of Pharmacology and Biochemistry, Central Research Laboratories, Yamanouchi Pharmaceutica
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USUDA Shinji
Departments of Biochemistry and Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutic
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KUROIWA Izumi
Departments of Biochemistry and Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutic
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Noshiro Osamu
Department Of Pharmacology And Biochemistry Central Research Laboratories Yamanouchi Pharmaceutical
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USUDA Shinji
Departments of Biochemistry and Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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NOSHIRO Osamu
Departments of Biochemistry and Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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KUROIWA Izumi
Departments of Biochemistry and Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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TERAI Michio
Departments of Biochemistry and Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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NOSHIRO Osamu
Department of Biochemistry, Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.
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