EFFECT OF PROSTAGLANDINS ON MUCOSAL BLOOD FLOW AND ASPIRIN-INDUCED DAMAGE IN THE CANINE STOMACH

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概要

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• This study deals with the action in anesthetized dogs of prostaglandin E<SUB>2</SUB> and F<SUB>2α</SUB> given into the celiac artery and the femoral vein on gastric mucosal blood flow and on gastric mucosal damage induced by aspirin. In the non-stimulated stomach, infusion of prostaglandin E<SUB>2</SUB> or F<SUB>2α</SUB> into the celiac artery resulted in a marked increase in mucosal blood flow and a sustained decrease, respectively. In contrast, an infusion of prostaglandin E<SUB>2</SUB> into the femoral vein produced a decrease in mucosal blood flow, whereas prostaglandin F<SUB>2α</SUB> produced a biphasic response: a transient increase followed by a decrease. It was observed that intravenously infused prostaglandin E<SUB>2</SUB>, while reducing mucosal blood flow, significantly diminished mucosal lesions, altered transmucosal potential differences and H+ back-diffusion induced by a topical application of aspirin. The findings indicate that the action of prostaglandins on gastric mucosal blood flow alters depending on the route of administration and that prostaglandins seem to exert gastric cytoprotection through mechanisms other than an increase in mucosal blood flow.

• 社団法人 日本薬理学会の論文

著者

• INATOMI Nobuhiro

  Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• MAKI Yoshitaka

  Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

関連論文

• EFFECT OF PROSTAGLANDINS ON MUCOSAL BLOOD FLOW AND ASPIRIN-INDUCED DAMAGE IN THE CANINE STOMACH
• Effects of a Proton Pump Inhibitor, AG-1749 (Lansoprazole), on Reflux Esophagitis and Experimental Ulcers in Rats.
• Differences in the Antisecretory Actions of the Proton Pump Inhibitor AG-1749 (Lansoprazole) and the Histamine H2-Receptor Antagonist Famotidine in Rats and Dogs.

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