SYNAPTIC FACILITATORY AND DEPRESSANT ACTIONS OF 3, 4-DIAMINOPYRIDINE: CORRELATION WITH ANTICURARE PROPERTIES
スポンサーリンク
概要
- 論文の詳細を見る
This study aimed to define the complete concentration-effect relationship for anticurare effects of 3, 4-diaminopyridine (3, 4-DAP) in the isolated sympathetic ganglion of the bullfrog. Synaptic transmission was monitored by extracellular and intracellular recordings of the postganglionic response to preganglionic stimulation. A previous study showed that in the bullfrog sympathetic ganglion 3, 4-DAP caused stimulus-bound repetitive postganglionic responses (SBR) to each single preganglionic stimulus. The concentration-effect relationship for 3, 4-DAP-induced SBR was bell-shaped, and the descending limb of the curve reflected progressive suppression of SBR while normal synaptic transmission was maintained. In the present study a detailed concentration-effect analysis of 3, 4-DAPs anticurare action also resulted in a bell-shaped curve nearly congruent with that for SBR. SBR and anticurare effects of 3, 4-DAP therefore occupy a common concentration-effect domain, and this suggests that a common mechanism (increased transmitter release) may account for both effects.
- 社団法人 日本薬理学会の論文
著者
-
SASAKI KAZUHIKO
Department of Physiology School of Medicine, Iwate Medical University
-
RIKER William
Department of Pharmacology, School of Medicine, The Oregon Health Sciences University
-
APATOFF Brian
University of Chicago, School of Medicine, Chicago
-
Riker William
Department of Pharmacology, School of Medicine, L221, The Oregon Health Sciences University
-
SASAKI Kazuhiko
Department of Physiology and Advanced Medical Science Research Center, School of Medicine, Iwate Medical University
関連論文
- Physiological and pharmacological characteristics of quisqualic acid-induced K^+-current response in the ganglion cells of Aplysia (アメフラシ神経節細胞におけるキスカル酸で引き起こされるK^+電流応答の生理学的薬理学的性質)
- The Role of Rho and Rho-Dependent Kinase in Serotonin-Induced Contraction Observed in Bovine Middle Cerebral Artery
- Modulatory Role of Protein Tyrosine Kinase Activation in the Receptor-induced Contractions of the Bovine Cerebral Artery
- Electrophysiological and Pharmacological Characterization of the K_ Channel Involved in the K^+-Current Responses to FSH and Adenosine in the Follicular Cells of Xenopus Oocyte
- Augmenting Effect of Serotonin on the Voltage-Dependent Ca^ Current and Subsequently Activated K^+ Current in Aplysia Neurons
- Blockade of ionotropic receptor responses by progesterone in the ganglion cells of Aplysia
- ATP suppresses the K^+ current responses to FSH and adenosine in the folliculer cells of Xenopus oocyte (Xenopus oocyte 卵胞細胞においてFSHおよびアデノシンで発生するK^+電流応答はATP受容体刺激によって抑制される)
- SYNAPTIC FACILITATORY AND DEPRESSANT ACTIONS OF 3, 4-DIAMINOPYRIDINE: CORRELATION WITH ANTICURARE PROPERTIES
- Biochemical and Immunological Characterization of Deoxyhypusine Synthase Purified from the Yeast Saccharomyces carlsbergensis
- Some New Observations on Caffeine-Induced Rhythmic Hyperpolarization in Frog Sympathetic Ganglion Cells.
- Regulation of dopamine-induced Na^+ current response by small G-protein RhoB or C and phospholipase D in Aplysia neurons