Effect of chronic angiotensin-converting enzyme blockade on pressor responses to exogenous angiotensin II, noradrenaline and vasopressin in deoxycorticosterone acetate salt (DOCA)-induced hypertensive rats.

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概要

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• Effect of chronic angiotensin converting enzyme blockade on the pressor response to exogenous angiotensin II, noradrenaline and vasopressin were evaluated in DOCA-salt induced hypertensive rats using teprotide. The blood pressure of rats receiving teprotide chronically was reduced markedly. The pressor responses to exogenous angiotensin II was accentuated, while that of noradrenaline and vasopressin were significantly reduced. It is concluded that besides the angiotensin converting enzyme blocking action, the decrease in sensitivity of the pressor response to noradrenaline and vasopressin may contribute towards the antihypertensive activity of teprotide given chronically.

• 公益社団法人 日本薬理学会の論文

著者

• LATIFF Aishah

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• GAN Ee-Kiang

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• ABAS Alias

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

関連論文

• Effect of captopril on converting enzyme activity in chemically sympathectomized, spontaneously hypertensive rats.
• Effect of chronic angiotensin-converting enzyme blockade on pressor responses to exogenous angiotensin II, noradrenaline and vasopressin in deoxycorticosterone acetate salt (DOCA)-induced hypertensive rats.

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