Stereoselective Enhancement of Nociception by Opioids in Different Strains of Mice

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of Mr2096, Mr2097, diprenorphine, (-)bremazocine and Mr2266 on jumping latencies were evaluated in Swiss, CXBK, C57BL, CXBH and CBA strains of mice. Mr2096 and Mr2097 respectively produced analgesia and hyperalgesia in these strains of mice. Thus their effects on nociception were mediated by stereoselective opioid receptors. Diprenorphine also produced hyperalgesia which might be mediated by both mu and kappa receptors. Kappa receptors also appeared to mediate hyperalgesia at least in Swiss and CBA strains, as both (-)bremazocine and Mr2266 shortened the jumping latencies.

著者

• RAMABADRAN Krishnaswami

  Department of Pharmacology, Faculty of Medicine, National University of Singapore

関連論文

• NEUROMUSCULAR EFFECTS OF SOME OPIOID AGONISTS AND ANTAGONISTS
• HYPERALGESIC EFFECT OF THE SELECTIVE KAPPA OPIOID AGONIST, U-50488H IN MICE
• Stereoselective Enhancement of Nociception by Opioids in Different Strains of Mice
• Failure to observe tolerance to the hyperalgesic effect of naloxone in mice.
• Nociceptive reactivity and precipitated abstinence in hypophysectomized rats.
• An analysis of precipitated withdrawal in rats acutely dependent on morphine.

スポンサーリンク