Specific 3H-cimetidine binding to receptors in the submandibular gland of the rat.

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概要

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• Recent studies indicate that the secretagogue action of histamine on the salivary gland is mediated via H<SUB>2</SUB>-receptors. In this study we attempt to characterize the histamine H<SUB>2</SUB>-receptors in the submandibular gland of the rat. The results show the presence of a specific <SUP>3</SUP>H-cimetidine binding site in the gland. However, the binding constants of this site are not fully characteristic of the specific <SUP>3</SUP>H-cimetidine-H<SUB>2</SUB>-receptor binding . They tend to indicate that the binding of <SUP>3</SUP>H-cimetidine to the gland membrane is similar to the well-characterized <SUP>3</SUP>H-cimetidine-imidazole recognition-receptor binding found in the membrane of the brain, gastric mucosae and atrium of various mammalian species.

• 公益社団法人 日本薬理学会の論文

著者

• Sim Meng

  Department Of Pharmacology Faculty Of Medicine National University Of Singapore

• ANG Seng

  Department of Pharmacology, Faculty of Medicine, National University of Singapore

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