Spin label study of the effect of ticlopidine on platelets.

スポンサーリンク

概要

• 論文の詳細を見る

• The effect of ticlopidine on platelet membrane fluidity was investigated using a spin label technique. Ticlopidine, when orally administered to rats, increased both the order parameter and the motion parameter, indicating a decrease in the membrane fluidity of platelets. On the other hand, the order parameter and the motion parameter decreased markedly when the platelets were aggregated by thrombin. Ticlopidine inhibited the thrombin-induced aggregation of platelets and caused a slight increase in order parameter and motion parameter in thrombinaggregated platelets. Judging from sodium dodecyl sulfate polyacrylamide gel electrophoresis, ticlopidine did not modify the electrophoretic pattern of platelet proteins appreciably. Ticlopidine decreased cholesterol/phospholipids molar ratio and increased slightly total amounts of proteins of the platelets. These results indicate that the inhibitory action by ticlopidine was accompanied by changes in membrane fluidity, and these changes were due to a perturbation of the membrane phospholipid core of the platelets by ticlopidine and/or its metabolites.

• 公益社団法人 日本薬理学会の論文

著者

• Setaka Morio

  Faculty Of Pharmaceutical Sciences Teikyo University

• KWAN TAKAO

  Faculty of Pharmaceutical Sciences, Teikyo University

• Kwan Takao

  Faculty Of Pharmaceutical Sciences Teikyo University

• HONGO Toshio

  Faculty of Pharmaceutical Sciences, Teikyo University

関連論文

• The Escherichia coli pldC Gene Encoding Lysophospholipase L_1 Is Identical to the apeA and tesA Genes Encoding Protease I and Thioesterase I, Respectively
• Red Blood Cells Highly Express Type I Platelet-Activating Factor-Acetylhydrolase (PAF-AH) Which Consists of the α_1/α_2 Complex
• Regulation of Activities of Cytidine 5'-Diphospho-Choline : 1-O-Alkyl-2-Acetyl-sn-Glycerol Cholinephosphotransferase, an Enzyme Responsible for de novo Synthesis of Platelet-Activating Factor, by Membrane Phospholipids
• Cloning, Expression and Characterization of Plasma Platelet-Activating Factor-Acetylhydrolase from Guinea Pig
• VESICULATION OF PLATELET PLASMA MEMBRANES INDUCED BY SYNTHETIC PHOSPHATIDYLCHOLINES
• ESR Studies of the Sulfite Radical Anion
• The Methylation of the Mercuric Ion by Methylcobaloximes
• The ESR Spectra of Alkyl Radicals Formed in UV-irradiated Trialkyl Phosphate Glasses
• ESR Evidence for the Destruction of the Four-membered Chelate Structure of Bis(O,O′-diethyldithiophosphato)oxovanadium(IV) by Pyridine Bases
• The Photosensitized Decomposition of Methane Adsorbed on Porous Vycor Glasses Coated with Metal Oxides at 77°K
• Electron-spin-resonance Studies of the Formation and Properties of the Trimeric Vanadyl Dibutylphosphate Complex
• ESR Studies of the (RO)2PSS Radicals in UV-Irradiated O,O′-Dialkyl Dithiophosphate Glasses
• A Novel Type of Methyl Radical Trapped in Porous Vycor Glass at 77°K
• The Role of Anion in the Demethylation Reaction of Methylcobalamin with Mercuric Salts
• The Ligation of Phosphine Derivatives and the Oxygen-binding Properties of the Cobalt Mesoporphyrin IX Dimethyl Ester in Toluene
• The Cation-radical Salts of p-Phenylenediamine. A Modified Method of Preparation and the Electrical Resistivity of the Salts
• Some Environmental Effects on the shf Lines in the ESR Spectra of Vanadyl Tetraphenylporphin
• Spin label study of the effect of ticlopidine on platelets.

もっと見る 閉じる

スポンサーリンク