Changes in 3H-spiperone, 3H-WB 4101 and 3H-dihydroalprenolol bindings to brain membranes produced by postnatal pretreatment with chlorpromazine in adult rats.

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概要

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• In order to elucidate possible mechanisms of the learning deficit produced by postnatal pretreatment with chlorpromazine (CPZ), changes in catecholamine receptors in the rat brain were investigated. Male neonates of Wistar strain rats were given s.c. 2 mg/kg/day of CPZ for 7 successive days from days 6 to 12 after birth. Effect of the postnatal pretreatment with CPZ on saturation constants for specific bindings of <SUP>3</SUP>H-spiperone, <SUP>3</SUP>H-WB 4101 and <SUP>3</SUP>H-dihydroalprenolol, respectively, in 8 brain regions was investigated at 60 days after birth. Significant decreases in B<SUB>max</SUB> values of <SUP>3</SUP>H-WB 4101 binding sites in the cortex, thalamus, hypothalamus, mid brain and medulla oblongata/pons and decreases in K<SUB>d</SUB> values of the binding sites in thalamus, hypothalamus and mid brain were observed in CPZ-pretreated rats when compared with corresponding B<SUB>max</SUB> and K<SUB>d</SUB> values obtained in saline-pretreated rats. Furthermore, significant decreases in both B<SUB>max</SUB> and K<SUB>d</SUB> values of <SUP>3</SUP>H-DHA binding sites in the thalamus were detected in CPZ-pretreated rats when compared with those obtained in saline-pretreated rats. However, no alterations in <SUP>3</SUP>H-spiperone binding sites in all brain regions were found between CPZ- and saline-pretreated rats. These results suggest that the learning deficit observed in CPZ-pretreated rats may be produced by a functional disorder of catecholaminergic, in particular α<SUB>1</SUB>-noradrenergic neurons in the brain.

• 公益社団法人 日本薬理学会の論文

著者

• KUNIHARA Mineo

  Behavioral Research Institute, Gunma University School of Medicine

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• Changes in 3H-spiperone, 3H-WB 4101 and 3H-dihydroalprenolol bindings to brain membranes produced by postnatal pretreatment with chlorpromazine in adult rats.

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