1H NMR spectroscopic studies of interactions between dimyristoylphosphatidylcholine (DMPC) and europium nitrate in the presence of tetracaine.

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概要

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• <SUP>1</SUP>H NMR spectroscopic studies have been carried out for multidispersed vesicles of DMPC and DOPC in the presence of Eu(NO<SUB>3</SUB>)<SUB>3</SUB> and anesthetics (tetracaine and lidocaine). <SUP>1</SUP>H NMR signals of DMPC vesicles disappeared, while those of DOPC did not, in the coexistence of Eu(N0<SUB>3</SUB>)<SUB>3</SUB> and the anesthetics. An addition of EDTA-Na<SUB>4</SUB> to this solution regained the signals of DMPC vesicles, implying cancellation of the effect of Eu(III) ions by chelating with EDTA anions. Intervesicular aggregation was proposed as a molecular mechanism responsible for the signal disappearance.

• 公益社団法人 日本薬理学会の論文

著者

• OGURA Yasumi

  Department of Pharmacology, School of Dentistry, Tohoka University

• KONDO Michio

  Analytical and Metabolic Research Laboratories, Sankyo Co. Ltd.

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• 1H NMR spectroscopic studies of interactions between dimyristoylphosphatidylcholine (DMPC) and europium nitrate in the presence of tetracaine.

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