Pharmacological effects of the tremorgenic mycotoxin fumitremorgin A.

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概要

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• Some pharmacological effects of a potent tremorgenic mycotoxin, fumitremorgin A (FTA), on the rabbit were studied. FTA (10-200 μg/kg, i.v.) caused clonic and tonic convulsion accompanied by nystagmus and miosis in conscious rabbits, after a latent period. Even in decorticated or decerebrated rabbits, FTA (100-200 μg/kg, i.v.) could induce violent motor effects similar to those observed in conscious rabbits. Under light anesthesia with urethane and chloralose, a higher dosage (more than 100 μg/kg) was needed to cause clonic and tonic convulsion. FTA facilitated phrenic nerve discharges as well as efferent discharges of the vagal nerve and the cervical sympathetic nerve. Hypertention induced by FTA was inhibited by phentolamine, while bradycardia and arrhythmia caused by this toxin was abolished by atropine or bilateral vagotomy. The electroencephalogram showed persistent strong arousal response after intravenous injection of FTA. A seizure pattern was never observed. It was suggested that the main site of action of FTA was in the brain stem.

• 公益社団法人 日本薬理学会の論文

著者

• NISHIYAMA Mariko

  Department of Experimental Pharmacology, Research Institute for Chemobiodynamics, Chiba University

関連論文

• HEMOLYSIS AND HYPERPOTASSEMIA IN RAT INDUCED BY THE THERMOSTABLE DIRECT HEMOLYSIN OF VIBRIO PARAHAEMOL YTICUS
• Pharmacological effects of the tremorgenic mycotoxin fumitremorgin A.

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