Studies on the efficacy of diethyxime as an antidote against organophosphorus intoxication in rats.

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概要

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• Diethyxime, a non-quaternary cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index, cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked anti-dotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphate (DFP) poisoning was not observed with this reactivator.

• 公益社団法人 日本薬理学会の論文

著者

• Pant B.p.

  Division Of Chemistry Defence Research And Development Establishment

• Jaiswal D.k.

  Division Of Chemistry Defence Research And Development Establishment

• GHOSH A.K.

  Division of Pharmacology, Defence Research and Development Establishment

• DUBE S.N.

  Division of Pharmacology, Defence Research and Development Establishment

• GUPTA S.

  Division of Pharmacology, Defence Research and Development Establishment

• JEEVARATHINAM K.

  Division of Pharmacology, Defence Research and Development Establishment

• KUMAR D.

  Division of Pharmacology, Defence Research and Development Establishment

• BATRA B.S.

  Division of Synthetic Chemistry, Defence Research and Development Establishment

関連論文

• Therapeutic Efficacy of a Few Diesters of Meso 2, 3-Dimercaptosuccinic Acid during Sub-Chronic Arsenic Intoxication in Rats
• Studies on the efficacy of diethyxime as an antidote against organophosphorus intoxication in rats.

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