Effect of L-threo-3,4-dihydroxyphenylserine (L-DOPS), an immediate precursor of norepinephrine, on the cerebral blood flow in rats.
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概要
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L-threo-3, 4-Dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) precursor, 3 mg/kg, i.v., increased the cerebral blood flow (CBF) in both the striatum and hippocampus as well as the mean arterial blood pressure (MABP) in urethane-anesthetized rats, as NE infusion did. The L-DOPS induced increase in CBF was inhibited by benserazide (3 mg/kg/hour), a peripheral aromatic L-amino acid decarboxylase inhibitor, and propranolol (3 mg/kg, i.p.), a β-adrenoceptor blocker as well. These results suggest that the effects of L-DOPS may be attributed to the action of NE formed from L-DOPS, and the action may be mediated by stimulation of β-adrenoceptor.
- 公益社団法人 日本薬理学会の論文
著者
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KATSUBE Junki
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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SATO Etsuro
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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IRIE Tsunemasa
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd.
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