Effect of MCI-176, a new calcium antagonist, on the calcium induced contraction of isolated porcine coronary arteries.

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概要

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• Calcium antagonistic activity of MCI-176, a new calcium antagonist, was compared with those of diltiazem and nifedipine in isolated depolarized porcine coronary arteries. MCI-176, diltiazem and nifedipine competitively inhibited calcium contraction of the large coronary arteries, and their pA<SUB>2</SUB> values were 7.49, 6.89 and 9.55, respectively. Similar competitive inhibition by MCI-176, diltiazem and nifedipine of calcium contraction was also observed in the small coronary arteries, and their pA<SUB>2</SUB> values were 7.38, 6.83 and 9.91, respectively. Although calcium antagonistic activity of nifedipine was several hundreds times more potent than MCI-176 and diltiazem, the action of nifedipine, unlike MCI-176 and diltiazem, favored the small coronary arteries rather than the large coronary arteries.

著者

• Ishibashi Akira

  Tsukuba Research Laboratories For Drug Discovery Eisai Co. Ltd.

• HORII Daijiro

  Tsukuba Pharmaceuticals Laboratory, Life Science Research Sector, Research Center, Mitsubishi Chemical Industries Limited

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• Effect of MCI-176, a new calcium antagonist, on the calcium induced contraction of isolated porcine coronary arteries.

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