Down-regulation of central serotonin S2 receptors after repeated treatment with quinupramine in rats.
スポンサーリンク
概要
- 論文の詳細を見る
The present studies were undertaken to determine whether the repeated administration of quinupramine caused down- or up-regulation of β-, α<SUB>2</SUB>-adrenergic, serotonin S<SUB>2</SUB>, imipramine and muscarinic cholinergic receptors, as had been demonstrated for tricyclic and atypical antidepressant drugs. Quinupramine administered at 10 mg/kg (p.o.) twice daily for 10 days caused a down-regulation of serotonin S<SUB>2</SUB> receptors in the frontal cortex of the rat as determined by [<SUP>3</SUP>H]-ketanserin binding. However, quinupramine did not alter the binding populations of β-adrenergic, muscarinic cholinergic and α<SUB>2</SUB>-adrenergic receptors in the rat brain as determined by the Scatchard analysis of the [<SUP>3</SUP>H]-ligand binding data. Differing from quinupramine, imipramine caused down-regulation of β-adrenergic and serotonin S<SUB>2</SUB> receptor bindings, and it caused sight but significant upregulation of muscarinic cholinergic receptor bindings. These results show that the antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system. Accordingly, quinupramine, chemically one of the typical tricyclic antidepressant drugs, seems to be pharmacologically one of the atypical antidepressant drugs, and it was suggested that the central serotonin system plays an important role in the antidepressant activity of quinupramine.
- 公益社団法人 日本薬理学会の論文
公益社団法人 日本薬理学会 | 論文
- Neurotoxin A2NTX Blocks Fast Inhibitory and Excitatory Transmitter Release From Presynaptic Terminals
- Loxiglumide, L - 364,718 and L - 365,260 Prevent the Inhibition of Spontaneous Acetylcholine Release from the Frontal Cerecral Cortex of Freely Moving Rat Peripherally Administered with Cholecystokinin - 8S
- A new device for the determination of microsomal cytochrome P-450 in renal tissue preparations from various species contaminated with mitochondria and hemoglobin.
- Leukocyte Recruitment to Peritoneal Cavity of Rats Following Formalin Injection : Role of Tachykinin Receptors
- Immunopharmacologic studies of D-penicillamine-L-cysteine disulfide.