Consecutive Treatment of Disulfiram Inhibits Ovarian Carbonyl Reductase Activity in Rats.

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概要

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• We investigated the effects of disulfiram (DS) on ovarian carbonyl reductase activity in rats to determine the influence of DS on female reproductive function. Three consecutive treatments with DS significantly inhibited ovarian carbonyl reductase activity as well as ovulation, dose-dependently. Single treatment with DS had no effect on ovarian carbonyl reductase activity. Our observations indicate that consecutive treatment with DS has an inhibitory action on female reproductive function, although DS is well-known to inhibit aldehyde dehydrogenase and dopamine β-hydroxylase.

• 公益社団法人 日本薬理学会の論文

著者

• Iwata Nobuhisa

  Division of Xenobiotic Metabolism and Disposition, National Institute of Hygienic Sciences

関連論文

• Consecutive Treatment of Disulfiram Inhibits Ovarian Carbonyl Reductase Activity in Rats.

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